Oldest University in the US (1636)
Harvard University
Oldest Foreign Bookstore in the US (1856)
Schoenhof's
Oldest Sporting Goods Store in the US (1867)
Brine's (in Belmont since 2004)
Oldest College Cooperative in the US (1882)
The Harvard Coop
Oldest Barber Shop in Massachusetts (1898)
LaFlamme
Oldest Poetry Bookstore in the US (1927)
Grolier
First soft-serve frozen yogurt (1972)
The Spa
Chains originating in Harvard Square
Crabtree & Evelyn, Joan & David shoes, The House of Blues, Jasmine/Sola, Origins, Cross

The Coop

LaFlamme

The Grolier